The Collaborative International Dictionary of English v.0.48:

Skunk \Skunk\, v. t.
   In games of chance and skill: To defeat (an opponent) (as in
   cards) so that he fails to gain a point, or (in checkers) to
   get a king. [Colloq. U. S.]
   [1913 Webster]

The Collaborative International Dictionary of English v.0.48:

Skunk \Skunk\, n. [Contr. from the Abenaki (American Indian)
   seganku.] (Zool.)
   Any one of several species of American musteline carnivores
   of the genus Mephitis and allied genera. They have two
   glands near the anus, secreting an extremely fetid liquid,
   which the animal ejects at pleasure as a means of defense.
   [1913 Webster]

   Note: The common species of the Eastern United States
         (Mephitis mephitica) is black with more or less white
         on the body and tail. The spotted skunk (Spilogale
         putorius), native of the Southwestern United States
         and Mexico, is smaller than the common skunk, and is
         variously marked with black and white.
         [1913 Webster]

   Skunk bird, Skunk blackbird (Zool.), the bobolink; -- so
      called because the male, in the breeding season, is black
      and white, like a skunk.

   Skunk cabbage (Bot.), an American aroid herb (Symplocarpus
      f[oe]tidus) having a reddish hornlike spathe in earliest
      spring, followed by a cluster of large cabbagelike leaves.
      It exhales a disagreeable odor. Also called swamp
      cabbage.

   Skunk porpoise. (Zool.) See under Porpoise.
      [1913 Webster]

WordNet (r) 3.0 (2006):

skunk
    n 1: a person who is deemed to be despicable or contemptible;
         "only a rotter would do that"; "kill the rat"; "throw the
         bum out"; "you cowardly little pukes!"; "the British call a
         contemptible person a `git'" [syn: rotter, dirty dog,
         rat, skunk, stinker, stinkpot, bum, puke,
         crumb, lowlife, scum bag, so-and-so, git]
    2: a defeat in a game where one side fails to score [syn:
       shutout, skunk]
    3: street names for marijuana [syn: pot, grass, green
       goddess, dope, weed, gage, sess, sens, smoke,
       skunk, locoweed, Mary Jane]
    4: American musteline mammal typically ejecting an intensely
       malodorous fluid when startled; in some classifications put
       in a separate subfamily Mephitinae [syn: skunk, polecat,
       wood pussy]
    v 1: defeat by a lurch [syn: lurch, skunk]

Moby Thesaurus II by Grady Ward, 1.0:

84 Moby Thesaurus words for "skunk":
   Cape polecat, animal, ape, bar, bear, beast, beat, blank, bulldoze,
   cavy, chimp, chimpanzee, clobber, coon, cream, cur, defeat utterly,
   dog, drub, ferret, foumart, glutton, groundhog, guinea pig,
   hedgehog, hound, hyena, insect, lambaste, larrup, lick, mongrel,
   monk, monkey, mousehound, opossum, overbear, overwhelm, paste, pig,
   polecat, porcupine, possum, prairie dog, prick, quill pig, raccoon,
   reptile, rotten egg, schmear, scum, serpent, shellac, shit,
   shithead, shut out, smear, snake, snow under, steamroller,
   stink ball, stink bomb, stinkard, stinker, stinkpot, swine, thrash,
   toad, turd, varmint, vermin, viper, warning sign, weasel, whelm,
   whelp, whistle-pig, whitewash, whomp, whop, wolverine, woodchuck,
   worm, zoril