The Collaborative International Dictionary of English v.0.48:

Offend \Of*fend\, v. t. [imp. & p. p. Offended; p. pr. & vb.
   n. Offending.] [OF. offendre, L. offendere, offensum; ob
   (see Ob-) + fendere (in comp.) to thrust, dash. See
   Defend.]
   1. To strike against; to attack; to assail. [Obs.] --Sir P.
      Sidney.
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   2. To displease; to make angry; to affront.
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            A brother offended is harder to be won than a strong
            city.                                 --Prov. xviii.
                                                  19.
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   3. To be offensive to; to harm; to pain; to annoy; as, strong
      light offends the eye; to offend the conscience.
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   4. To transgress; to violate; to sin against. [Obs.]
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            Marry, sir, he hath offended the law. --Shak.
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   5. (Script.) To oppose or obstruct in duty; to cause to
      stumble; to cause to sin or to fall. [Obs.]
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            Who hath you misboden or offended.    --Chaucer.
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            If thy right eye offend thee, pluck it out . . . And
            if thy right hand offend thee, cut it off. --Matt.
                                                  v. 29, 3O.
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            Great peace have they which love thy law, and
            nothing shall offend them.            --Ps. cxix.
                                                  165.
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The Collaborative International Dictionary of English v.0.48:

Offend \Of*fend"\, v. i.
   1. To transgress the moral or divine law; to commit a crime;
      to stumble; to sin.
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            Whosoever shall keep the whole law, and yet offend
            in one point, he is guilty of all.    --James ii.
                                                  10.
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            If it be a sin to covet honor,
            I am the most offending soul alive.   --Shak.
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   2. To cause dislike, anger, or vexation; to displease.
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            I shall offend, either to detain or give it. --Shak.
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   To offend against, to do an injury or wrong to; to commit
      an offense against. "We have offended against the Lord
      already." --2 Chron. xxviii. 13.
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WordNet (r) 3.0 (2006):

offend
    v 1: cause to feel resentment or indignation; "Her tactless
         remark offended me" [syn: pique, offend]
    2: act in disregard of laws, rules, contracts, or promises;
       "offend all laws of humanity"; "violate the basic laws or
       human civilization"; "break a law"; "break a promise" [syn:
       transgress, offend, infract, violate, go against,
       breach, break] [ant: keep, observe]
    3: strike with disgust or revulsion; "The scandalous behavior of
       this married woman shocked her friends" [syn: shock,
       offend, scandalize, scandalise, appal, appall,
       outrage]
    4: hurt the feelings of; "She hurt me when she did not include
       me among her guests"; "This remark really bruised my ego"
       [syn: hurt, wound, injure, bruise, offend, spite]

Moby Thesaurus II by Grady Ward, 1.0:

94 Moby Thesaurus words for "offend":
   affront, aggrieve, anger, annoy, appall, blemish, blot, breach,
   break, call names, chagrin, commit sin, contravene, deface,
   disfigure, disgruntle, disgust, dishonor, disoblige, displease,
   distress, disturb, do amiss, do wrong, dump on, dysphemize,
   embarrass, err, exasperate, excite, fleer at, flout, fret, gall,
   gibe at, give offense, give offense to, give umbrage, grieve,
   gross out, horrify, humiliate, hurl a brickbat, hurt,
   hurt the feelings, infract, infringe, insult, irritate, jeer at,
   jibe at, look a fright, look a mess, look bad, look like hell,
   look something terrible, mar, miff, mock, nauseate, needle, nettle,
   offend the eye, outrage, pain, pique, provoke, put down, put off,
   rankle, rattle, repel, repulse, revolt, rile, ruffle, scandalize,
   scoff at, shock, sicken, sin, slight, snub, spoil, sting, taunt,
   transgress, treat with indignity, trespass, turn the stomach,
   uglify, upset, vex, wound