The Collaborative International Dictionary of English v.0.48:

Spite \Spite\, n. [Abbreviated fr. despite.]
   1. Ill-will or hatred toward another, accompanied with the
      disposition to irritate, annoy, or thwart; petty malice;
      grudge; rancor; despite. --Pope.
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            This is the deadly spite that angers. --Shak.
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   2. Vexation; chargrin; mortification. [R.] --Shak.
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   In spite of, or Spite of, in opposition to all efforts
      of; in defiance or contempt of; notwithstanding.
      "Continuing, spite of pain, to use a knee after it had
      been slightly injured." --H. Spenser. "And saved me in
      spite of the world, the devil, and myself." --South. "In
      spite of all applications, the patient grew worse every
      day." --Arbuthnot. See Syn. under Notwithstanding.

   To owe one a spite, to entertain a mean hatred for him.
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   Syn: Pique, rancor; malevolence; grudge.

   Usage: Spite, Malice. Malice has more reference to the
          disposition, and spite to the manifestation of it in
          words and actions. It is, therefore, meaner than
          malice, thought not always more criminal. " Malice . .
          . is more frequently employed to express the
          dispositions of inferior minds to execute every
          purpose of mischief within the more limited circle of
          their abilities." --Cogan. "Consider eke, that spite
          availeth naught." --Wyatt. See Pique.
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The Collaborative International Dictionary of English v.0.48:

Spite \Spite\, v. t. [imp. & p. p. Spited; p. pr. & vb. n.
   Spiting.]
   1. To be angry at; to hate. [Obs.]
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            The Danes, then . . . pagans, spited places of
            religion.                             --Fuller.
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   2. To treat maliciously; to try to injure or thwart.
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   3. To fill with spite; to offend; to vex. [R.]
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            Darius, spited at the Magi, endeavored to abolish
            not only their learning, but their language. --Sir.
                                                  W. Temple.
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WordNet (r) 3.0 (2006):

spite
    n 1: feeling a need to see others suffer [syn: malice,
         maliciousness, spite, spitefulness, venom]
    2: malevolence by virtue of being malicious or spiteful or nasty
       [syn: cattiness, bitchiness, spite, spitefulness,
       nastiness]
    v 1: hurt the feelings of; "She hurt me when she did not include
         me among her guests"; "This remark really bruised my ego"
         [syn: hurt, wound, injure, bruise, offend,
         spite]

Moby Thesaurus II by Grady Ward, 1.0:

81 Moby Thesaurus words for "spite":
   Anglophobia, Russophobia, Schadenfreude, abhorrence, abomination,
   animosity, annoy, antagonism, anti-Semitism, antipathy, aversion,
   belligerence, bigotry, bitchiness, bitterness, bone to pick,
   cattiness, clash, clashing, collision, conflict, contention,
   crow to pick, crow to pluck, despite, despitefulness, detestation,
   discomfit, disconcert, dislike, execration, friction,
   gall and wormwood, gloating pleasure, grudge, hate, hatred,
   hostility, hurt, ignoring, ill, ill will, in defiance of,
   in spite of, injure, irritate, loathing, malevolence, malice,
   maliciousness, malignity, misandry, misanthropy, misogyny, needle,
   notwithstanding, odium, offend, peeve, pet peeve, pique, provoke,
   put out, quarrelsomeness, race hatred, racism, rancor,
   regardless of, repugnance, resentment, spitefulness, spleen,
   unholy joy, upset, venom, vex, vials of hate, vials of wrath,
   vindictiveness, wound, xenophobia