The Collaborative International Dictionary of English v.0.48:

Sophisticate \So*phis"ti*cate\, v. t. [imp. & p. p.
   Sophisticated; p. pr. & vb. n. Sophisticating.] [LL.
   sophisticatus, p. p. of sophisticare to sophisticate.]
   To render worthless by admixture; to adulterate; to damage;
   to pervert; as, to sophisticate wine. --Howell.
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         To sophisticate the understanding.       --Southey.
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         Yet Butler professes to stick to plain facts, not to
         sophisticate, not to refine.             --M. Arnold.
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         They purchase but sophisticated ware.    --Dryden.
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   Syn: To adulterate; debase; corrupt; vitiate.
        [1913 Webster] Sophisticate