The Collaborative International Dictionary of English v.0.48:

Fatigue \Fa*tigue"\, v. t. [imp. & p. p. Fatigued; p. pr. &
   vb. n. Fatiguing, n.] [Cf. F. fatiguer. See Fatigue, n.]
   To weary with labor or any bodily or mental exertion; to
   harass with toil; to exhaust the strength or endurance of; to
   tire.

   Syn: To jade; tire; weary; bore. See Jade.
        [1913 Webster]

Moby Thesaurus II by Grady Ward, 1.0:

27 Moby Thesaurus words for "fatiguing":
   boresome, boring, devitalizing, draining, enervating, enfeebling,
   exhausting, fatiguesome, grueling, irksome, killing, punishing,
   sapping, straining, stressful, stupefyingly boring, stuporific,
   tiresome, tiring, toilsome, trying, weakening, weariful, wearing,
   wearisome, wearying, yawny