1. 
[syn: man-made, semisynthetic, synthetic]
The Collaborative International Dictionary of English v.0.48:
man-made \man-made\ adj.
   Not of natural origin; prepared or made by humans;
   artificial; of substances, made by chemical reaction rather
   than extracted from a natural source; as, man-made fibers;
   man-made gems. Opposed to natural.
   Syn: semisynthetic, synthetic.
        [WordNet 1.5]
WordNet (r) 3.0 (2006):
man-made
    adj 1: not of natural origin; prepared or made artificially;
           "man-made fibers"; "synthetic leather" [syn: man-made,
           semisynthetic, synthetic]