The Collaborative International Dictionary of English v.0.48:

Wretched \Wretch"ed\, a.
   1. Very miserable; sunk in, or accompanied by, deep
      affliction or distress, as from want, anxiety, or grief;
      calamitous; woeful; very afflicting. "To what wretched
      state reserved!" --Milton.
      [1913 Webster]

            O cruel! Death! to those you are more kind
            Than to the wretched mortals left behind. --Waller.
      [1913 Webster]

WordNet (r) 3.0 (2006):

wretched
    adj 1: of very poor quality or condition; "deplorable housing
           conditions in the inner city"; "woeful treatment of the
           accused"; "woeful errors of judgment" [syn: deplorable,
           execrable, miserable, woeful, wretched]
    2: characterized by physical misery; "a wet miserable weekend";
       "spent a wretched night on the floor" [syn: miserable,
       wretched]
    3: very unhappy; full of misery; "he felt depressed and
       miserable"; "a message of hope for suffering humanity";
       "wretched prisoners huddled in stinking cages" [syn:
       miserable, suffering, wretched]
    4: morally reprehensible; "would do something as despicable as
       murder"; "ugly crimes"; "the vile development of slavery
       appalled them"; "a slimy little liar" [syn: despicable,
       ugly, vile, slimy, unworthy, worthless, wretched]
    5: deserving or inciting pity; "a hapless victim"; "miserable
       victims of war"; "the shabby room struck her as
       extraordinarily pathetic"- Galsworthy; "piteous appeals for
       help"; "pitiable homeless children"; "a pitiful fate"; "Oh,
       you poor thing"; "his poor distorted limbs"; "a wretched
       life" [syn: hapless, miserable, misfortunate,
       pathetic, piteous, pitiable, pitiful, poor,
       wretched]

Moby Thesaurus II by Grady Ward, 1.0:

207 Moby Thesaurus words for "wretched":
   abject, abominable, adverse, affecting, afflicted, afflictive,
   antagonistic, arrant, atrocious, awful, base, beastly, beggarly,
   beneath contempt, bitter, blameworthy, bleak, brutal, cheap,
   cheerless, cheesy, comfortless, common, conflicting, contemptible,
   contrary, counter, counteractive, crummy, crushed, cut up, debased,
   deep-troubled, degraded, deplorable, depraved, depressing,
   depressive, desolate, despairing, despicable, despondent,
   detestable, detrimental, difficult, dire, dirty, discomforting,
   disconsolate, discontented, disgusting, dismal, dismaying,
   distressful, distressing, doleful, dolorific, dolorogenic,
   dolorous, dreadful, dreary, egregious, enormous, execrable, fetid,
   filthy, flagrant, forlorn, foul, fulsome, gaudy, gimcracky, grave,
   grievous, grim, gross, hard, harmful, hateful, heart-stricken,
   heart-struck, heartsick, heinous, hopeless, horrible, horrid,
   hostile, humorless, ignoble, in bad humor, in opposition, indolent,
   infamous, infestive, inimical, joyless, lamentable, little,
   loathsome, lousy, low, low-down, lumpen, mangy, mean, measly,
   melancholy, meretricious, mirthless, miserable, monstrous,
   mournful, moving, nasty, nefarious, noisome, not easy, notorious,
   obnoxious, odious, offensive, opposed, opposing, opposite,
   out of humor, out of sorts, outrageous, painful, paltry, pathetic,
   petty, piteous, pitiable, pitiful, pleasureless, poignant, poky,
   poor, rank, regrettable, reprehensible, reptilian, repulsive,
   rigorous, rotten, rubbishy, rueful, ruthful, sad, saddening,
   scabby, scandalous, schlock, scrubby, scruffy, scummy, scurvy,
   scuzzy, servile, shabby, shameful, sharp, shocking, shoddy,
   sinister, slumlike, slummy, small, sordid, sore, sorrowful, sorry,
   sorryish, squalid, stressful, stricken, suicidal, terrible,
   too bad, touching, trashy, troublesome, troublous, trumpery,
   trying, two-for-a-cent, two-for-a-penny, twopenny,
   twopenny-halfpenny, uncheerful, uncheery, unclean, uncomfortable,
   unfavorable, unhappy, unjoyful, unmentionable, unmirthful,
   unsmiling, untoward, valueless, vile, villainous, woebegone,
   woeful, worst, worthless