The Collaborative International Dictionary of English v.0.48:

Despiteful \De*spite"ful\, a. [See Despite, and cf.
   Spiteful.]
   Full of despite; expressing malice or contemptuous hate;
   malicious. -- De*spite"ful*ly, adv. -- De*spite"ful*ness,
   n.
   [1913 Webster]

         Haters of God, despiteful, proud, boasters. --Rom. i.
                                                  30.
   [1913 Webster]

         Pray for them which despitefully use you. --Matt. v.
                                                  44.
   [1913 Webster]

         Let us examine him with despitefulness and fortune.
                                                  --Book of
                                                  Wisdom ii. 19.
   [1913 Webster]

WordNet (r) 3.0 (2006):

despiteful
    adj 1: showing malicious ill will and a desire to hurt;
           motivated by spite; "a despiteful fiend"; "a truly
           spiteful child"; "a vindictive man will look for
           occasions for resentment" [syn: despiteful, spiteful,
           vindictive]

Moby Thesaurus II by Grady Ward, 1.0:

32 Moby Thesaurus words for "despiteful":
   acrid, antagonistic, antipathetic, belligerent, bitchy, bitter,
   cattish, catty, caustic, clashing, colliding, conflicting,
   detestable, evil, full of hate, hateful, hostile, malevolent,
   malicious, malignant, quarrelsome, rancorous, repugnant,
   set against, sore, spiteful, unlikable, venomous, vicious,
   virulent, vitriolic, wicked