The Collaborative International Dictionary of English v.0.48:

Afresh \A*fresh"\, adv. [Pref. a- + fresh.]
   Anew; again; once more; newly.
   [1913 Webster]

         They crucify . . . the Son of God afresh. --Heb. vi. 6.
   [1913 Webster]

WordNet (r) 3.0 (2006):

afresh
    adv 1: again but in a new or different way; "start afresh";
           "wanted to write the story anew"; "starting life anew in
           a fresh place" [syn: afresh, anew]

Moby Thesaurus II by Grady Ward, 1.0:

25 Moby Thesaurus words for "afresh":
   ab ovo, again, anew, another time, as new, bis, da capo, de novo,
   ditto, encore, freshly, from scratch, from the beginning, lately,
   new, newly, of late, once again, once more, over, over again,
   recently, twice over, two times, yet again