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The Collaborative International Dictionary of English v.0.48:

Loco \Lo"co\, v. t. [imp. & p. p. Locoed; p. pr. & vb. n. Locoing.] To poison with loco; to affect with the loco disease; hence (Colloq.), to render insane or mad. "The locoed novelist." --W. D. Howells. [Webster 1913 Suppl.]