spite of

Webster's Dictionary (1913)

in opposition to all efforts of; in defiance or contempt of; notwithstanding. “Continuing, spite of pain, to use a knee after it had been slightly injured.” H. Spenser. “And saved me in spite of the world, the devil, and myself.” Robert South “In spite of all applications, the patient grew worse every day.” John Arbuthnot See Syn. under Notwithstanding.

From the entry Spite.

Webster’s Revised Unabridged Dictionary (1913), from GCIDE 0.54