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The Collaborative International Dictionary of English v.0.48:

Meddle \Med"dle`\, v. i. [imp. & p. p. Meddled; p. pr. & vb. n. Meddling.] [OE. medlen to mix, OF. medler, mesler, F. m[^e]ler, LL. misculare, a dim. fr. L. miscere to mix. [root]271. See Mix, and cf. Medley, Mellay.] [1913 Webster] 1. To mix; to mingle. [Obs.] [1913 Webster] More to know Did never meddle with my thoughts. --Shak. [1913 Webster] 2. To interest or engage one's self; to have to do; -- in a good sense. [Obs.] --Barrow. [1913 Webster] Study to be quiet, and to meddle with your own business. --Tyndale. [1913 Webster] 3. To interest or engage one's self unnecessarily or impertinently, to interfere or busy one's self improperly with another's affairs; specifically, to handle or distrub another's property without permission; -- often followed by with or in. [1913 Webster] Why shouldst thou meddle to thy hurt? --2 Kings xiv. 10. [1913 Webster] The civil lawyers . . . have meddled in a matter that belongs not to them. --Locke. [1913 Webster] To meddle and make, to intrude one's self into another person's concerns. [Archaic] --Shak. [1913 Webster] Syn: To interpose; interfere; intermeddle. [1913 Webster]