The Collaborative International Dictionary of English v.0.48:
mainline \main"line`\ (m[=a]n"l[imac]n`) v. t. 1. to inject (illegal drugs) into the vein; as, he preferred to mainline heroin rather than sniff coke. [WordNet 1.5]WordNet (r) 3.0 (2006):
mainline v 1: inject into the vein; "She is mainlining heroin"