The Collaborative International Dictionary of English v.0.48:

lipophobic \lipophobic\ adj. (Chem.)
   Not soluble in lipids, or in non-polar solvents; -- of
   chemical substances or parts of molecules; as, the lipophobic
   end of a detergent is solvated in water. Contrasted to
   lipophilic or nonpolar.
   [WordNet 1.5]