The Collaborative International Dictionary of English v.0.48:

Despondency \De*spond"en*cy\, n.
   The state of desponding; loss of hope and cessation of
   effort; discouragement; depression or dejection of the mind.
   [1913 Webster]

         The unhappy prince seemed, during some days, to be sunk
         in despondency.                          --Macaulay.
   [1913 Webster]

WordNet (r) 3.0 (2006):

despondency
    n 1: feeling downcast and disheartened and hopeless [syn:
         despondency, despondence, heartsickness,
         disconsolateness]

Moby Thesaurus II by Grady Ward, 1.0:

43 Moby Thesaurus words for "despondency":
   Schmerz, Slough of Despond, acedia, apathy, blank despondency,
   cave of Trophonius, cave of despair, death wish, dejectedness,
   dejection, depression, despair, desperateness, desperation,
   despondentness, disconsolateness, discouragement, disheartenment,
   dispiritedness, down trip, downcastness, downer, downheartedness,
   drooping spirits, forlornness, heartlessness, hopelessness,
   low spirits, lowness, lowness of spirit, malaise, no exit, no way,
   no way out, oppression, pessimism, self-destructive urge,
   sinking heart, sloth, spiritlessness, suicidal despair,
   taedium vitae, weariness of life