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The Collaborative International Dictionary of English v.0.48:

Colocynth \Col"ocynth\, n. [L. colocynthis, Gr. ?. Cf. Coloquintida.] (Med.) The light spongy pulp of the fruit of the bitter cucumber (Citrullus colocynthis, or Cucumis colocynthis), an Asiatic plant allied to the watermelon; coloquintida. It comes in white balls, is intensely bitter, and a powerful cathartic. Called also bitter apple, bitter cucumber, bitter gourd. [1913 Webster]