The Collaborative International Dictionary of English v.0.48:

Supreme \Su*preme"\, a. [L. supremus, superlative of superus
   that is above, upper, fr. super above: cf. F. supr[^e]me. See
   Super-, and cf. Sum.]
   1. Highest in authority; holding the highest place in
      authority, government, or power.
      [1913 Webster]

            He that is the supreme King of kings. --Shak.
      [1913 Webster]

   2. Highest; greatest; most excellent or most extreme; utmost;
      greatist possible (sometimes in a bad sense); as, supreme
      love; supreme glory; supreme magnanimity; supreme folly.
      [1913 Webster]

            Each would be supreme within its own sphere, and
            those spheres could not but clash.    --De Quincey.
      [1913 Webster]

   3. (Bot.) Situated at the highest part or point.
      [1913 Webster]

   The Supreme, the Almighty; God.
      [1913 Webster]

U.S. Gazetteer (1990):

Supreme, LA (CDP, FIPS 74235)
  Location: 29.85959 N, 90.99262 W
  Population (1990): 1020 (293 housing units)
  Area: 7.4 sq km (land), 0.1 sq km (water)

Moby Thesaurus II by Grady Ward, 1.0:

190 Moby Thesaurus words for "supreme":
   absolute, acmatic, all-absorbing, all-knowing, all-powerful,
   all-seeing, all-wise, almighty, apical, ascendant, at the head,
   authoritarian, authoritative, authorized, autocratic, best, boss,
   boundless, brilliant, capital, cardinal, champion, changeless,
   chief, choice, clothed with authority, commanding, competent,
   consequential, considerable, consummate, controlling, creating,
   creative, crowning, dominant, duly constituted, elect, elite,
   eminent, empowered, eternal, eternally the same, everlasting,
   ex officio, excellent, extreme, final, first, first-class,
   first-rate, for the best, foremost, general, glorious, good,
   governing, great, greatest, hallowed, handpicked, head, headmost,
   hegemonic, hegemonistic, highest, holy, immortal, immutable,
   imperative, important, in ascendancy, in charge, in chief,
   in the ascendant, incomparable, infinite, influential, inimitable,
   just, last, leading, limitless, loftiest, loving, luminous, main,
   majestic, making, master, masterful, masterly, matchless, maximal,
   maximum, merciful, meridian, meridional, mighty, momentous,
   monocratic, most, numinous, official, omnipotent, omnipresent,
   omniscient, one, optimal, optimum, outstanding, overmost,
   overriding, overruling, paramount, peerless, perfect, permanent,
   perpetual, picked, plenipotentiary, potent, powerful, predominant,
   predominate, preeminent, premier, prepollent, preponderant,
   preponderate, prepotent, prestigious, prevalent, primary, prime,
   principal, prize, prominent, puissant, quintessential, radiant,
   ranking, regnant, regulating, regulative, regulatory, reigning,
   ruling, sacred, select, senior, shaping, sovereign, sublime,
   substantial, summital, superb, superior, superlative, surpassing,
   timeless, tip-top, top, top-notch, topmost, totalitarian, towering,
   transcendent, ubiquitous, ultimate, unbounded, unchanging,
   undefined, unequaled, unexcelled, unlimited, unmatchable,
   unmatched, unparalleled, unrivaled, unsurpassable, unsurpassed,
   upmost, uppermost, utmost, uttermost, vertical, very best, weighty,
   zenithal