The Collaborative International Dictionary of English v.0.48:

Destitute \Des"ti*tute\, a. [L. destitutus, p. p. of destituere
   to set away, leave alone, forsake; de + statuere to set. See
   Statute.]
   1. Forsaken; not having in possession (something necessary,
      or desirable); deficient; lacking; devoid; -- often
      followed by of.
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            In thee is my trust; leave not my soul destitute.
                                                  --Ps. cxli. 8.
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            Totally destitute of all shadow of influence.
                                                  --Burke.
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   2. Not possessing the necessaries of life; in a condition of
      want; needy; without possessions or resources; very poor.
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            They wandered about in sheepskins and goatskins;
            being destitute, afflicted, tormented. --Heb. xi.
                                                  37.
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The Collaborative International Dictionary of English v.0.48:

Destitute \Des"ti*tute\, v. t.
   1. To leave destitute; to forsake; to abandon. [Obs.]
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            To forsake or destitute a plantation. --Bacon.
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   2. To make destitute; to cause to be in want; to deprive; --
      followed by of. [Obs.]
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            Destituted of all honor and livings.  --Holinshed.
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   3. To disappoint. [Obs.]
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            When his expectation is destituted.   --Fotherby.
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WordNet (r) 3.0 (2006):

destitute
    adj 1: poor enough to need help from others [syn: destitute,
           impoverished, indigent, necessitous, needy,
           poverty-stricken]
    2: completely wanting or lacking; "writing barren of insight";
       "young recruits destitute of experience"; "innocent of
       literary merit"; "the sentence was devoid of meaning" [syn:
       barren, destitute, devoid, free, innocent]

Moby Thesaurus II by Grady Ward, 1.0:

47 Moby Thesaurus words for "destitute":
   badly off, bankrupt, bereft of, broke, broken, busted, deficient,
   depleted, deprived of, destitute of, devoid of, divested,
   down-and-out, drained, empty, exhausted, failed, fortuneless,
   hard up, homeless, impecunious, impoverished, in need,
   in receivership, in the gutter, in the red, in want, indigent,
   innocent, insolvent, landless, moneyless, necessitous, needy,
   on the rocks, out of funds, penniless, penurious, poor, poverty,
   poverty-stricken, propertyless, ruined, stripped, void, without,
   without a sou